Teaching Process Oriented Guided Inquiry Learning (POGIL) is student-centered teaching and incorporates active, team-based learning. POGIL will also be involved in guided research using carefully crafted materials that instruct and guide students to build and rebuild their knowledge. This paper describes the basic concepts of POGIL, its features, and how it can improve the quality of student learning in the new millennium. Besides, it is proposed that POGIL be integrated into the teaching of Sterile Pharmaceutical Preparation Course organized by the Training Management Division, the Ministry of Health, Malaysia. Examples of how POGIL will be implemented is shown in this paper. The aims of this paper are to generate interest among educators, with the hope of eventually developing a kind of resource sharing community through POGIL. Hence, POGIL seems to make learning more interesting and can be as the introduction to a new concept for education in Malaysia.