Malaria is an infectious disease that is still a public health problem in Indonesia. Based on the report on the value of Annual Parasite Incidence in Palangka Raya City was 0.16 per 1000 inhabitants and malaria cases were found in 46 cases in 2017. With malaria cases still being discovered, Palangka Raya City was appointed as one of the regencies/cities to be assessed in malaria elimination programs in Central Kalimantan. This research aims to analyze the risk factors associated with malaria incidence in the City of Palangka Raya. This is quantitative research with case-control design to assess the associated risk factors (independent variable) with malaria incidence (dependent variable). Total sample in research this is 30 case and 30 control with proportionate random sampling. There is a relationship between job (p=0.000), the existence of mosquito breeding sites (p=0.001), use of mosquito nets (p=0.001) with malaria incidence. There is no relationship between the existence of cattle pens (p=0.117), installation of mosquito nets (p=0.488), health services for malaria prevention efforts (p=0.584) with malaria incidence. The dominant factor related to malaria incidence is the job (p=0.0001). There is a relationship between job, the existence of mosquito breeding sites, the use of mosquito nets with malaria incidence in Palangkaraya City while the existence of cattle pens, installation of mosquito nets and health services to prevent malaria not related.