Coronavirus disease 2019 (COVID-19), is an infectious disease with various clinical presentation from asymptomatic to severe pneumonia and death. It is caused by the infection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). One of the important mechanisms that underlies the severe respiratory syndrome of COVID-19 is the oxidant-antioxidant imbalances owing to the inflammatory response and excessive oxidative stress. The antioxidant defense system plays a role in balancing these excessive reactive species. This literature study aims to review several therapeutic approaches particularly antioxidative agents that may be favorable in the treatment of COVID-19.