SARS-CoV-2 is a new type of coronavirus that has never been previously identified in humans. The increase in the number of cases took place quite quickly, and spread to various countries in a short time and caused the death of the COVID-19 pandemic. Nurses are at higher risk of contracting COVID-19 because they are in closer and longer contact with patients. This situation can have a negative impact on the mental health of nurses. Nurses on the guard Nurses become highly vulnerable to many work-related hazards and experience a tremendous amount of emotional stress. The purpose of this study was to identify the factors that influence nurses' anxiety during the COVID-19 pandemic through Systematic Review. This study uses a systematic review method that presents an evidence-based assessment of nurses' anxiety during the COVID-19 pandemic. This research was conducted by searching for articles in the database GoogleScholar, SagePub, ProQuest, and ScienceDirect. The keywords in this systematic review are "Emotion" and "Anxiety", and "COVID-19" and "Pandemic". The search was limited to English and data sources on articles published from 2020-2021. Systemtic review reports are written using the PRISMA checklist. The selection process for articles was carried out so that 13 articles were obtained. The factors that cause anxiety in nurses during the COVID-19 pandemic are based on a review of articles in categories based on the most common factors, including: gender (female nurse), work unit (hospital or room), risk perception, age, marital status, years of service, workload, information and training, availability of PPE, and level of education. It is important to hold training programs related to COVID-19 for nurses, to build a positive image of nurses. Hospitals should expend more efforts to ensure supplies of personal protective equipment