High calorie diet without proper balance of physical excersises is a major factor to many health issues such as obesity, fat accumulation and organs failure. Fat accumulation in kidney can lead up to atherosclerosis and cause major problem in the organ through its mechanism that causes fibrogenesis. The aim of this research is to determine the effect of physical exercise and high-calorie diet on kidney histopathology. This study is conducted with 27 Mus musculus that were divided to 3 groups (negative control, positive control and experiment) with each group got different treatment. Negative control group was given no D40 nor physical exersice, positive control was given D40 without physical exersice and experimental group was given D40 and physical exercise. The kidneys from these mice then microscopically tested to see the histopathological changes in the form of inflammatory cell infiltration, hemorrhage, cell necrosis, glomerular adhesion, and microscopic swelling. Data was analyzed with Kruskal-Wallis Test to determine the difference between each test group using the help of Statistical Package for the Social Science (SPSS) Version 25. 30 mice were observed histologically with HE stain. The results of the Kruskal-Wallis test showed a value of p < 0.05 for glomerular adhesion, swelling, and inflammatory cell infiltration. The only histopathological changes that had significant difference in all of its group was inflamatory cell infiltration. Physical exercise and high-calorie diet showed an effect on the kidney in the form of glomerular adhesion, swelling and inflammatory cell infiltration as evidenced by the results of the analysis test.

Physical Exersice

High-Calorie Diet

Kidney Histopathology

Mus musculus

Diet