Medicine, Health & Food

Medicine, Health & Food

RESISTANCE AND SUSCEPTIBILITY PATTERNS OF S. aureus TO VANCOMICIN AND LINEZOLID

Pages: 6  ,  Volume: 36  ,  Issue: 1 , September   2019
Received: 15 Sep 2019  ,  Published: 27 September 2019
Views: 36  ,  Download: 14

Authors

# Author Name
1 Tuvei Susan Mamusavu

Abstract

Background: Given the rising complication for treating S.aureus infections, information regarding the medical impact of antimicrobial agents remains vital for decision making. Scientific studies investigating patterns of susceptibility of S.aureus to first line drugs such as vancomycin and linezolid have divergent views given that some scientists established S.aureus to be more susceptible to vancomicin while others established S.aureus to be more susceptible to linezolid. This makes it impossible to single out the most effective antibiotic between vancomicin and linezolid. Aim: To investigate the resistance and susceptibility pattern of S.aureus to vancomicin and linezolid. Method: Pus samples from diabetic patients with foot ulcers (DPFUs) were collected for S. aureus screening and susceptibility test. Results: S. aureus isolated from DPFUs at Vihiga County Referral Hospital, Kenya had a susceptibility rate of 36% and 60% to vancomycin and linezolid respectively. Recommendations: Linezolid having the highest susceptibility rate should be used as the first line antibiotic for treating bacterial infections which appear to be resistant to most of the commonly used antibiotics.

Keywords

  • Susceptibilty
  • S.aureus
  • vancomicin
  • References

    Caffrey, A. R., Quilliam, B. J., and LaPlante, K. L. (2010). Comparative effectiveness of linezolid and vancomycin among a national cohort of patients infected with methicillin-resistant Staphylococcus aureus . Antimicrobial Agents and Chemotherapy , 54 (10), 4394-4400.

    Ehsan, M. M., Fatima, G., Ismail, O. M., and Memon, Z. (2014). Effiicacy of vancomycin verses linezolid against coagulase-negative staphylococc in various clinical specimens. Journal of Ayub Medical College Abbottabad , 26 (2), 137-140.

    Kishore, S., Verma, D., and Siddique, M. (2014). Comparison of in-vitro activities of linezolid and vancomycin against Staphylococcus aureus  isolated om a tertiary care hospital. Journal of Clinical and Diagnostic Research , 8 (5), 12-15.

    Olivares, M. F., Orozco, R. H., Garrido, S. R., Rodriguez-Vidigal, F. F., Tome, A. V., and Marcos, M. R. (2011). Activity of vancomycin, ciprofloxacin, daptomycin and linezolid against coagulase-negative staphylococci bacteremia. Rev Esp Quimioter , 24 (2), 74-78.

    Swoboda, S., Fritz, S., Martignoni, M. E., Feldhues, R. A., Hoppe-Tichy, T., Buchler, M. W., et al. (2005). Varrying linezolid susceptibilty of vancomycin-resistant enterococcus faecium isolates during therapy: A case report. Journal of antimicrobial chemotherapy , 56, 787-789.

    Watkins, R. R., Lemonovich, T. L., and File, T. M. (2012). Anevidence-based review of linezolid for the treatment of methicillin-resistant Staphylococcus aureus  (MRSA): Place in therapy. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles

    Wunderink, R. G., Niederman, M. S., Kollef, M. H., Shorr, A. F., Kunkel, M. J., Baruch, A., et al. (2012, March 13). Linezolid in methicillin-resistant Staphylococcus aureus  nosocomial pneumonia: ArRandomized,. Retrieved from http://cid.oxfordjournals.org/