Yellow fever is a viral infection, which is continuously causing disease in tropical regions such as America and Africa. The virus, which causes Yellow fever is called as flavivirus. YF predominantly distresses persons and cardinals. Infected mosquitoes are main source of transmission of YF. Vector of YF commonly called as yellow fever virus (YFV), can leads hazardous hemorrhagic and potentially fatal disease. There is great need of vaccination campaigns for appropriate control and prevention of this fatal disease. Major Outburst of this epidemic is mainly due to following reasons: (1) Aedes aegypti reinvasion: in area where urban settings are made (2) Rapid moving of rural people to urban areas (3) diminished Immunity in living organisms. Effective and modern vaccinations are available but more updated information is needed to target specific zones of world which are at high risk of YF. The target of this study was to estimate the Cause, life cycle, diagnosis, treatments of YF virus and to gather optimal control and prevention strategies. However, it is concluded that YF had been rapidly emerging and highly fatal disease in humans and non- human primates throughout the civilizations