Chemistry & Chemical Engineering

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Analgesic Efficacy of Leaf and Root Decoction of Salacia korthalsiana Mig. (Polipog)

Volume: 63  ,  Issue: 1 , October    Published Date: 28 October 2020
Publisher Name: IJRP
Views: 59  ,  Download: 23
DOI: 10.47119/IJRP1006311020201499

Authors

# Author Name
1 Nyra Jane P. Jarito
2 Ma. Lourdes C. Alvarez

Abstract

This study was conducted to determine the analgesic efficacy of the leaf and root decoction of Salacia korthalsiana Miq (Polipog) found in Brgy. Imelda Mondragon Northern Samar, Philippines. Decocted Root of polipog has a boiling point of 91.1°C , reddish brown color, unpleasant odor, and a pH of 6.39 which is weakly acidic. It is miscible in both water and ethanol and immiscible in toluene which indicates that it is polar. Decocted Leaf of polipog has a boiling point of 90.9°C, yellowish in color, pleasant odor, and a pH of 6.42 which is weakly acidic. The decocted leaf is miscible in both water and ethanol and immiscible in toluene which indicates that it is also polar. The presence of functional groups was also determined using Fourier Transform Infrared Spectroscopy (FTIR). Graphs of FTIR revealed spectra with peaks found to be amine, amide, alkene, carboxylic acid and aromatic functional groups. Following the Acetic-acid induced writhing procedure, the lowest average number of squirms was recorded using the paracetamol (positive control) and the highest average number of squirms was obtained using distilled water (negative control). The decocted leaf and root have almost the same results in terms of number of squirms and in percent reduction of squirms. Analysis of variance revealed that there is no significant difference between the analgesic effect of decocted leaf and root of polipog and paracetamol. This result means that the decocted leaf and root of polipog has analgesic efficacy and it is comparable to the commercial medicine.

Keywords

  • Polipog leaf
  • polipog root
  • decoction
  • analgesic efficacy
  • writhing test
  • References

    Gupta, AK et.al. (2015). Analgesic and anti inflammatory properties of Gelsolin in acetic acid induced writhing, tail immersion and carrageenan induced edema in mice. PLOS ONE. DOI:10.1371/journal.pone.0135558pp1-16.

    Rauf A, Jehan, Noor, et.al. (2017). Pain relief from analgesics to alternative therapies. Retrieved from http://dx.doi.org/10.5772/intechopen.68631 on Dec. 20,2017.