Background: Nasopharyngeal carcinoma (NPC) is carcinoma arising from nasopharyngeal mucosa that shows light microscopic of squamous differentiation. Data from GLOBOCAN (Global Burden of Cancer) 2018, nasopharyngeal carcinoma ranks fifth based on the incidence of new cases from all malignancies in Indonesia. The high mortality rate indicates that NPC management through surgery, radiotherapy, and chemotherapy have not been completely satisfactory. Recently, Programmed Death-Ligand 1 (PD-L1) inhibitor has developed which is an effective cancer immunotherapy. Abnormal expression of PD-L1 in various types of malignant tumors is associated with invasion, decreased T-lymphocyte infiltration, poor prognosis, and survival time. Objective: This study aimed to assess expression of Programmed Death-Ligand 1 (PD-L1) immunohistochemistry staining in nasopharyngeal carcinoma at Rumah Sakit Umum Pusat Haji Adam Malik Medan 2018. Material and Method: This study is descriptive and cross-sectional, which enrolled 50 PD-L1 stained slides of NPC biopsy and assessed by Histo-score. Expression of PD-L1 negative is 0-99, and positive is 100-300. Result: From 50 specimens in this study, we found that NPC patients were dominated by men (72%), with mean age 46,5?13,1 years-old. Positive expression of PD-L1 staining are 23 (46%) specimens, and negative expression of PD-L1 staining are 27 (54%) specimens. Conclusion: Expression of PD-L1 immunohistochemistry staining in this study were found fewer positive expressions compared to negative expressions.